Hermann AM Mucke^1
1HM Pharma Consultancy, A-1160, Wien, Austria

Noteworthy recent developments in the patent literature of relevance to pharmaceutical and medical research and development, set to be published in Volume 7 Issue 3 of Pharmaceutical Patent Analyst. The full article is available to view here.

December

January

WO/2017/207600

New treatment of SMA

Inventors: Blättler T, McCarthy KD, Sanwald Ducray P & Schädeli Stark 

Assignee: F Hoffmann-LaRoche AG (Basel, Switzerland)

MeSH keywords: neuroprotective agents; spinal muscular atrophy

Published: 7 December 2017

WO/2017/210523

KLRG1 signaling therapy

Inventors: Greenberg S, Gulla SV & Thompson KE

Assignee: The Brigham & Women's Hospital, Boston (MA, USA)

MeSH keywords: lectins, C-type; melanoma; receptors, immunologic

Published: 7 December 2017

WO/2017/214579

Compositions & methods for treating osteoporosis

Inventors: Pilz R, Boss G & Kalyamaraman H

Assignee: The Regents of the University of California, Oakland (CA, USA)

MeSH keywords: cobamides; isosorbide mononitrate; osteoporosis

Published: 14 December 2017

WO/2017/216792

PERK inhibitors & uses thereof in treating diseases associated with aggregation-prone proteins

Inventors: Lederkremer GZ, Leitman J, Eiger H, Offen D, Ganz J & Portinoy M

Assignee: Ramot at Tel-Aviv University Ltd (Tel Aviv, Israel)

MeSH keywords: basal ganglia; endoplasmic reticulum stress; Huntington's disease

Published: 21 December 2017

WO/2017/217935

Use of miR-198 in treating & diagnosing cutaneous squamous cell carcinoma

Inventors: Sampath P, Gopinath S & Quah S

Assignee: Agency for Science, Technology & Research (Singapore)

MeSH keywords: follistatin-related proteins; miR-198, human; skin neoplasms; squamous cell carcinoma

Published: 21 December 2017

WO/2017/222713

A GPR119-based signaling system in the murine eye regulates intraocular pressure in a sex-dependent manner

Inventors: Straiker A

Assignee: Indiana University Research & Technology Corp., Indianapolis (IN, USA)

MeSH keywords: 2-oleyl glycerol ether; G-protein-coupled receptor 119; glaucoma

Published: 28 December 2017

WO/2017/223260

PU.1 inhibitors

Inventors: Wilson WD, Boykin DW, Poon G, Steidl U & Anthony-Debré I

Assignee: Albert Einstein College of Medicine, Inc., Atlanta (GA, USA); Georgia State University Research Foundation, Inc., Atlanta (GA, USA)

MeSH keywords: acute myeloid leukemia; acute promyelocytic leukemia; proto-oncogene proteins

Published: 28 December 2017

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WO/2018/001565

Use of Lyso-GB1 as a druggable target

Inventors: Cozma C & Bauer P

Assignee: Centogene AG (Rostock, Germany)

MeSH keywords: animal model; Gaucher disease; glucosylsphingosine

Published: 4 January 2018

WO/2018/001666

Modulators of vault RNAs for use in the treatment of diseases

Inventors: Horos R, Hentze M & Sachse C

Assignee: European Molecular Biology Laboratory (Heidelberg, Germany)

MeSH keywords: autophagy; sequestosome-1 protein; vault ribonucleoprotein particle

Published: 4 January 2018

WO/2018/005812

A new & potent class of TLR agonists

Inventors: Beutler B & Boger DL

Assignee: The Scripps Research Institute, La Jolla (CA, USA); The Board of Regents of the University of Texas System, Austin (TX, USA)

MeSH keywords: infection; stereoisomerism; toll-like receptors

Published: 4 January 2018

WO/2018/007801

A probe for targeting & manipulating mitochondrial function using quantum dots

Inventors: Naasani I

Assignee: Nanoco Technologies Ltd (Manchester, UK)

MeSH keywords: mitochondria; quantum dots

Published: 11 January 2018

WO/2018/010856

HRI activators useful for the treatment of cardiometabolic diseases

Inventors: Zarei M, Vázquez Carrera M, Vázquez Cruz S, Leiva Martínez R & Pujol Bech E

Assignee: Universitat de Barcelona (Barcelona, Spain)

MeSH keywords: eIF-2 kinase; fibroblast growth factors; metabolic syndrome

Published: 18 January 2018

WO/2018/013930

Mechanical opening of lipid bilayers by molecular nanomachines

Inventors: Tour JM, Pal R, Garcia V & Nilewski L

Assignee: William Marsh Rice University, Houston (TX, USA)

MeSH keywords: drug delivery

Published: 18 January 2018

WO/2018/017888

Multimeric OX40 binding molecules & uses thereof

Inventors: Wang Bt-Y, Rosner DR, Baliga R & Keyt BA

Assignee: IGM Biosciences, Inc., Mountain View (CA, USA)

MeSH keywords: cellular immunity; OX40 receptor; recombinant proteins

Published: 25 January 2018

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Source: Mucke HAM. Patent highlights from December 2017 to January 2018. Pharmaceutical Patent Analyst. 7(3), 111-119 (2018)