3-(Benzyloxy)-1-(5-[18F]fluoropentyl)-5-nitro-1H-indazole: A PET radiotracer to measure acetylcholinesterase in brain
Research presented at the Anesthesiology® 2016 annual meeting shows an experimental drug with promise in treating Alzheimer’s disease in mice.
A new compound has been shown by researchers at the Walter and Eliza Hall Institute (Melbourne, Australia) and Servier (Neuilly-sur-Seine, France) to block a protein essential to the sustained growth of up to a quarter of all cancers.
A team from The Scripps Research Institute (La Jolla, CA, USA) has identified a novel anti-obesity, anti-diabetes drug target.
A Heterologous Multiepitope DNA Prime/Recombinant Protein Boost Immunisation Strategy for the Development of an Antiserum against Micrurus corallinus (Coral Snake) Venom
In this work we describe the mapping, by the SPOT-synthesis technique, of potential B-cell epitopes from five putative toxins from M. corallinus, which were used to design two multiepitope DNA strings for the genetic immunisation of female BALB/c mice. Results demonstrate that sera obtained from animals that were genetically immunised with these multiepitope constructs, followed by booster doses of recombinant proteins lead to a 60% survival in a lethal dose neutralisation assay.