Ebola nucleocapsid modeled to near-atomic resolution

For the first time, researchers from the Okinawa Institute of Science and Technology Graduate University (OIST; Onna, Japan) have imaged the structure of a central component of the Ebola virus at a near-atomic resolution.

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The study, published recently in Nature, focused on the nucleocapsid, which encloses the virus’ genetic material. The team isolated nucleoprotein–RNA complexes, which make up the core of nucleocapsids, to a high degree of purity and analyzed these using a cryo-electron microscope (cryo-EM).

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