Dark Matter of the human genome: Protein drug targets

A data base of 802 novel proteins (Open Reading Frame, ORF) was generated from the human genome. Using motifs and domain analysis, these ORFs were classified into druggable class of proteins. A novel transporter (CREF) and a secreted (SGPX) protein was identified as cancer target. ORF fingerprints for cancer, diabetes and neurological diseases were developed.

Go to the profile of Ramaswamy Narayanan
Apr 29, 2016
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Go to the profile of Ramaswamy Narayanan

Ramaswamy Narayanan

Professor, Biological Sciences, Florida Atlantic University, Boca Raton, FL

I am a biochemist/molecular biologist and a cancer researcher. A Ph.D. in biochemistry from the National University of Ireland, Dublin, I have worked in federal institutions (NIH & CDC), in academia (Yale University & Memorial Sloan Kettering Cancer Center) and in industry (Hoffmann-La Roche AG). For the last 18 years, I have been at the Florida Atlantic University as a Professor in Biology. My research interests are interdisciplinary across the fields of biology, chemistry, engineering and medicine. Over the last three decades, my research has revolved around drug target(s) discovery by mining the human genome using bioinformatics. I am focusing on the areas of druggable targets/chemical leads discovery and repurposed medicine for various therapeutic areas to facilitate accelerated drug discovery and development.

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