Dark Matter of the human genome: Protein drug targets
A data base of 802 novel proteins (Open Reading Frame, ORF) was generated from the human genome. Using motifs and domain analysis, these ORFs were classified into druggable class of proteins. A novel transporter (CREF) and a secreted (SGPX) protein was identified as cancer target. ORF fingerprints for cancer, diabetes and neurological diseases were developed.